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| Brand | MultiSciences |
| CatNum | 70-EK1124 |
| Product Name | Human Proprotein Convertase 9/PCSK9 ELISA Kit |
| Customs Name | Human Proprotein Convertase 9/PCSK9 ELISA Kit |
| Application | ELISA |
| Reactivity | Human |
| Assay Type | Sandwich ELISA |
| Suitable Sample Type | serum, plasma, cell culture supernates |
| Format | 96-well strip plate |
| Storage | 4 (unopened) standard stored at -20, others stored at 4 (opened) |
| Shipping Condition | 4 |
| Sample Volume | 10 l (prediluted) |
| Sensitivity | 3.39 pg/ml |
| Standard Curve Range | 62.50 - 4000 pg/ml |
| Spike Recovery Range | - |
| Mean Spike Recovery | - |
| CV of Intra plate | 1.7 % - 7.6 % |
| CV of Inter plate | 2.4 % - 5.8 % |
| Release Date | 2015/11/26 |
| Components | 96-well polystyrene microplate coated with a monoclonal antibody against PCSK9 Human PCSK9 Standard, lyophilized PCSK9 Detect Antibody Streptavidin-HRP Assay Buffer (10) Substrate (TMB) Stop Solution Washing Buffer (20) Plate Covers |
| Describtion | This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PCSK9. The Human Proprotein Convertase 9/PCSK9 is for research use only. Not for diagnostic or therapeutic procedures. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme belonging to the proteinase K subfamily of the secretory subtilase family. It is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol, inducing LDLR degradation. Variants of PCSK9 can reduce or increase circulating cholesterol. Other variants are associated with a rare autosomal dominant familial hypercholesterolemia (HCHOLA3). The mutations increase its protease activity, reducing LDLR levels and preventing the uptake of cholesterol into the cells. |
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